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HLA-B*1502-bound peptides: implications for the pathogenesis of carbamazepine-induced Stevens-Johnson syndrome

Khan, 2013, 2014)

Unlike single-target peptides, Cerebrolysin contains a balanced composition of low molecular weight neuropeptides (under 10,000 Da) and free amino acids that collectively mimic the biological functions of endogenous neurotrophic factors including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), glial cell line-derived neurotrophic factor (GDNF), and ciliary neurotrophic factor (CNTF)

IS-induced ROS formation triggers the switching of vascular smooth muscular cells to the osteoblastic phenotype, which induces cardiovascular risk